Congenital Tracheal Stenosis (CTS) is a rare birth defect requiring surgical interventions when it affects more than 30% of the trachea. Slide tracheoplasty, the current standard of care, is associated with reinterventions including the need for intraluminal stenting leading to increased airway infections. We propose a novel Bio-Synthetic Graft for long segment tracheal reconstructions in CTS patients. Preliminary bench performance testing, using lamb tracheas, shows that the Bio-Synthetic Graft reconstructed tracheas have comparable radial, axial and bending stiffness in hyperextension to healthy tracheas and resist collapse when subjected to bending in flexion. These results suggest that Bio-Synthetic Graft could be a promising alternative to existing solutions for long segment CTS.
Novel Bio-Synthetic Graft for Tracheal Reconstruction in Pediatric Patients With Congenital Tracheal Stenosis: In Vitro Studies of Axial, and Bending Biomechanics
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Karkhanis, T, Zafar, F, Juarez, B, Morales, DL, & Haridas, B. "Novel Bio-Synthetic Graft for Tracheal Reconstruction in Pediatric Patients With Congenital Tracheal Stenosis: In Vitro Studies of Axial, and Bending Biomechanics." Proceedings of the 2019 Design of Medical Devices Conference. 2019 Design of Medical Devices Conference. Minneapolis, Minnesota, USA. April 15–18, 2019. V001T10A006. ASME. https://doi.org/10.1115/DMD2019-3226
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