Self-monitoring of blood glucose has become an important and critical tool for effective management of diabetes. A closed-loop, real-time sensing and dispensing system, however, has been elusive. We describe here, a novel MEMS-based sensor intended to measure, in realtime, the concentration of glucose in a solution. The device utilizes a bi-material membrane with a functional hydrogel layer that swells reversibly, and in proportion to, the presence of glucose. The hydrogel is composed of 2-hydroxyethyl methacrylate (HEMA) functionalized with 3-acrylamidophenylboronic acid (AAPBA) groups as the glucose-sensitive moiety. Phenylboronic acid (PBA) derivatives interact with glucose by forming a charged complex, causing the hydrogel to swell by solvent intake .
- Nanotechnology Institute
Real-Time Glucose Sensing Using a MEMS-Based Bi-Material Deflecting Membrane
Mariserla, S, Leseman, Z, & Mackin, TJ. "Real-Time Glucose Sensing Using a MEMS-Based Bi-Material Deflecting Membrane." Proceedings of the ASME 2006 Frontiers in Biomedical Devices Conference. ASME 2006 Frontiers in Biomedical Devices Conference. Irvine, California, USA. June 8–9, 2006. pp. 21-22. ASME. https://doi.org/10.1115/NANOBIO2006-18013
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